Incinerator Deutsch

Megapark Casino Freiburg

Die Größten Stadien Größten Stadien Europa Video

Größten Stadien Kundenrezensionen. mit dem Menschen verwandt und haben die größten Г„hnlichkeit mit ihm? Diese Aussage ist falsch; der Beweis ist. Das brauchst. Die 5 größten Startup Fehler - demeviusaventures.be Hallo Felix und Sebstian, irgendwo in diesen Stadium befinde ich mich gerade, wovon ihr redet. Größten Stadien Europas. mit dem Menschen verwandt und haben die grГ¶​Гџten Г„hnlichkeit mit ihm? Diese Aussage ist falsch; der Beweis ist, dass Allah im. Größten Stadien Kundenrezensionen Aber dann sollen die Cosmics auch noch den größten Diamanten des Kosmos Kurti und Dirk bewerben sich darum​. Aber dann sollen die Cosmics auch noch den größten Diamanten des Kosmos Kurti und Dirk bewerben sich darum, die olympische Flamme ins Stadion.

Die Größten Stadien

mit dem Menschen verwandt und haben die größten Г„hnlichkeit mit ihm? Diese Aussage ist falsch; der Beweis ist, dass Allah im Quran die Stadien der. Größten Stadien Kundenrezensionen. mit dem Menschen verwandt und haben die größten Г„hnlichkeit mit ihm? Diese Aussage ist falsch; der Beweis ist. Größten Stadien Kundenrezensionen Aber dann sollen die Cosmics auch noch den größten Diamanten des Kosmos Kurti und Dirk bewerben sich darum​.

Four Seven For both groups clinical longterm outcome was statistically comparable but showed a trend to higher all-cause mortality in patients presenting with NSTEMI, in which diagnostic and therapeutic angiograms were performed delayed.

Patients with ACS and occluded LCX without ST-segment elevation might have a benefit of early revascularisation and should therefore be diagnosed earlier e.

Roth, Ch. Weiser, B. Heidinger, H. Schreiber, C. Former studies reported that this challenging goal usually requires high efforts. The study was conducted from August, 23rd to September, 20th, The intervention was the availability of a dedicated ET.

In the control group no ET was available. The availability of the ET was randomized to three equally distributed shifts per day morning, day, night.

The ET rotas were concealed for clinical staff. Information about availability of ETs was marked with an alert sign at triage point and registration counter.

To compare delay times we used a Mann-Whitney-U-test. Results During the study period, in total patients received an ECG recording for different reasons.

In the interventional group patients This represents a Risk Ratio of 5. Conclusion Implementing an ECG technician in the ED is feasible to reach a higher percentage of patients within the recommended 10 minutes benchmark of guideline requirements compared to business as usual.

Havel, H. Ein wichtiges Zeitfenster stellt in dieser Hinsicht das Patientendelay dar, welches die Zeit zwischen Beginn des Brustschmerzes und Alarmierung des Rettungsdienstes zeigt.

Durch Massenmedienkampagnen kann das Patientendelay positiv beeinflusst werden. Juli und Anhand dieser wurde das Patientendelay des Jahres analysiert.

Inkludiert wurden alle Patienten, die in diesem Zeitraum ambulant oder durch den Rettungsdienst zugewiesen und mit Myokardinfarkt an unserer Abteilung vorstellig wurden.

August hospitalisiert wurden. Die demographische Daten zeigt Tabelle 4. Vogel, S. Farhan, S. Hahne, I.

Kozanli, R. Huber 3rd Med. Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna Background and Aim Due to the fact that there is only few data on long-term mortality in patients with hyperglycemia hospitalized with acute coronary syndrome, this study aimed to show the impact of elevated admission glucose on 4-year mortality in patients with NSTE-ACS.

Vogel et al. Table 5: B. In patients the glucose level at admission was missing, another patients had evident diabetes and were excluded from the analyses.

A follow-up concerning all-cause mortality up to four years was obtained. Results Patient with hyperglycemia were older In-hospital mortality, as well as four-year mortality was higher in patients with hyperglycemia In a Cox proportional hazard model the admission glucose level was an independent predictor for 4-year mortality Table 5.

Conclusion An elevated glucose level in patients hospitalized with acute coronary syndrome without ST-segment elevation is associated with worse long-term outcome.

Wallner, M. Schmidjell, H. Lafenthaler, W. Goebel, J. Westreicher, L. Keiler, S. Karnitschnig, R. Ablauf im Herzkatheterlabor in praxisnahen Flow-Charts abzubilden.

Beer, G. Werba, S. Nickl, A. Mitterbauer, M. Zimmermann, L. Wutzlhofer, H. Ankersmit, M. Lichtenauer Christian Doppler Laboratory for the Diagnosis and Regeneration of Cardiac and Thoracic Diseases, Medical University Vienna Background Chemokines are multifunctional mediators that are involved in development and homeostatic, stem-cell survival, wound healing and immune responses, as well as triggering chemotaxis and angiogenesis.

Diagnostic analysis of cytokines and chemokines in serum or plasma has become an important issue in several disease conditions.

However, cytokines and chemokines are usually not considered to be very stable after blood collection, which might therefore alter test results.

Thus, the aim of the pilot study was to obtain better knowledge about stability of these mediators in blood samples for interpretation of test results.

Wallner et al. Holzwart, D. Beer et al. Results Interestingly all examined mediators rise when samples were stored above room temperature for more than 4 hours in serum tubes.

Conclusions These data indicate that most cytokine and chemokine levels remain stable when analyzed within a short interval after venipuncture.

EDTA plasma seems to be the most suitable for stability reasons and should be used for analysis of these mediators. Cardiac metabolism of glucose is very tightly regulated to maintain the variable energy demand that is required by cardiac tissue.

Energy metabolism of the cardiac myocyte can be regulated within seconds up to a few minutes or chronically regulated within the time frame of hours to days.

However, in coronary heart disease, this activation becomes deleterious. In myocardial ischemia, inhibition or decreased gene expression of pyruvate dehydrogense kinase is necessary in order to shift myocardial metabolism towards the fetal phenotype, thus metabolising more glucose than fat in order to preserve myocardial integrity.

Methods Myocardial tissue probes derive from the right auricle of patients undergoing cardiac surgery. A small part of the right auricle is removed when the heart is put on extra-corporal circulation.

By doing so, we are able to compare ischemic and non-ischemic tissue of the same patient. Results In our microarray experiments, we find that, in particular, pyruvate dehydrogense kinase isoform 4 is significantly less expresses under nebivolol both during O2 perfusion and simulated ischemia, an effect practically negligible under atenolol.

Here, nebivolol also exhibits a unique cardio-protective property, different from standard beta-blockers. We find that, without the influence of beta-blockers, there is no significant regulation of pyruvate dehydrogense kinase-expression during myocardial ischemia.

There is just a trend towards a decrease in pyruvate dehydrogense kinase-Gene expression. There is, however a significant difference between the expression of PDK during myocardial ischemia in the presence of atenolol 3.

Especially patients with angina may profit from this particular property of nebivolol over atenolol. Affymetrix-Microarrays wurden verwendet, um mehr als microRNAs zu analysieren.

Die diastolische Spannung und die Kontraktionskinetik blieben von Sunitinib unbeeinflusst. Im Expressionsmuster der analysierten microRNAs zeigte sich nach 24h kein Unterschied zwischen unbehandelten und mit Sunitinib inkubierten Kardiomyozyten.

Doleschal, P. Rainer, Z. Saad, K. Groschner, H. Pieske, D. Abbildung 6: B. Doleschal et al. Dzilic, M. Kreibich, M.

Hasun, A. Baumgartner, D. Santer, P. Moser, B. Podesser, K. IS and AAR were expressed as percentage of the left ventricle. However, viable myocardium in the ischemic area AAR-IS was significantly larger in group 2 group 1: In this model, protective effects of different cardioplegic solutions can be evaluated.

Additionally, the decrease of CF after 2h of reperfusion suggests that damage of vital myocardium is further enhanced after a longer reperfusion time.

Thus, improvement of endothelial protection might be an interesting therapeutic target to gain better outcome in these highrisk patients.

Dziodzio1, A Juraszek1, D. Zimpfer1, V. Scheikl1, M. Stoiber1, M. Grimm2, H. Schima1, M. The aim of the study was to evaluate different sites of primary entry tears and the propagation of the dissecting membrane, ante- and retrograde, in an experimental model of acute type B aortic dissection.

Methods The entire thoracic aortic aorta including the supraaortic branches was harvested from 26 adult pigs. An intimal tear of 15 mm was created via contralateral incisions sites 20 mm downstream the origin of the left subclavian artery.

In 13 cases the dissection was created at the concavity and in 13 cases at the convexity. The aortic annulus was then sewn into a silicon ring of a driving chamber.

The distal aorta was connected to a tubing with adjustable resistance elements. The circulation was driven by the pneumatically driven Vienna heart to mimic aortic flow and pressure.

The median antegrade propagation length of the dissecting membrane was 65 mm. The median retrograde propagation length in primary entry tears at the convexity was 20 mm and was stopped by the left subclavian artery.

Conclusions In this experimental model of acute type B aortic dissection, we confirmed that many type B dissections do also have a retrograde component.

At the convexity, this component is stopped by the left subclavian artery as an anatomic barrier.

At the concavity, the propagation of the dissecting membrane may extend up to the ascending aorta and may therefore cause retrograde type A dissection.

These findings may substantiate clinical need for treatment of type B dissections with a primary entry tear at the concavity.

Gasser, A. Holzwart, H. For example, a few regulatory T-cells control a wide spectrum of the inflammatory cascade. Ischemic injury leads to left ventricular remodelling and oxidative stress and inflammation are key elements in this context.

Leukocyte-derived markers such as myeloperoxidase MPO correlates with outcome in ischemic heart disease. In our present work using microarray technique, we have found that, in T-cell mediated immunity generally, a noteworthy down-regulation is brought about by beta-blockers.

From our investigations we suspect that most important, unique pleiotropic effects of nebivolol may be centered around favourable effects upon T-cell mediated response to ischemia.

In our microarray experiments we found an upregulation of MPO expression in the presence of nebivolol as well as in the presence of atenolol both in hypoxic as well as in well oxygenated conditions, as can be seen below.

There is a differential regulation between different beta-blockers during myocardial ischemia, which warrant further investigation.

We believe that there are complex pleiotropic effects of beta-blockers on immunity. Such pleiotropic effects have received more attention recently.

Our preliminary results show that beta-blockers inhibit the expression of T-cell immunity related genes during experimental hypoxia and we find that during experimental ischemia, there is an up-regulation of MPO-expression.

In the light of JUPITER and other recent publications on modulating inflammation by pleiotropic effects of cardiovascular drugs, the specific property of immune modulation by beta-blockers in myocardial ischemia may warrant further attention.

However, a further detailed exploration on both expression and molecular level is certainly needed. Gasser, E. Some exciting developments help elaborate the regulation of PAK activity and identify downstream signalling targets.

Considering these recent findings, we investigate their regulation during experimental myocardial ischemia. Results After 30 minutes of myocardial hypoxia we find that there is no significant regulation of PDK-expression during myocardial ischemia.

There is just a trend towards a decrease in PAK4-Gene expression. There is, however, a significant difference between the expression of PAK4 during myocardial ischemia in the presence of nebivolol 0.

There is, however a significant difference between the expression of DDAH during myocardial ischemia in the presence of atenolol Conclusion In the present study we find that the myocardial expression of DDAH is reduced in the presence of nebivolol in both normoxia as well as hypoxia.

The measured decrease of DDAH seen under nebivolol but not with atenolol both during normoxia and hypoxia could be a measure for the increased availability of NO brought about by nebivolol as a feed back control.

This is of interest since several steps in the pathways of interaction have remained unclear as yet. Figure 7: R.

Gasser et al. The recent advances in understanding these new regulators PAK family and their targets could explain some of the cellular cardioprotective effects that have been attributed to beta-blockers during myocardial ischemia.

Specific cardioprotection of beta-blockers may thus at least partially be explained by PAKs decisive role played in myocardial integrity.

Wolbank2, S. Charwat1, K. Ali1, R. Hofer-Warbinek3, R. Huber4, G. ADMA is recognised as a plasma marker of increased cardiovascular risk but it is unclear whether it ever accumulates to sufficient levels to affect NO pathways.

On the other hand it is possible that a feed back mechanism exists which regulates DDAH expression upon the availability of NO.

In this context, it has to be mentioned that nebivolol can stimulate an increase of endothelial NO, which becomes available at the vascular smooth muscle and induces vaso-relaxation.

Nebivolol seems to interact with the endothelial NO pathway in two complementary ways: it increases NOS activity and reduces the NOscavenging radical superoxide anion, by re-directing deranged NOS activity.

We have previously shown the immediate decrease of the myocardial blood flow after intracoronary mesenchymal stem cell MSC delivery.

Methods Farm pigs were subjected to min occlusion of the mid left anterior descending coronary artery followed by reperfusion. Myocardial blood flow MBF was measured by combination of pressure wire and special designed infusion catheter under maximal hyperemia caused by adenosine.

The global left ventricular ejection fraction EF was measured 1-month post cell therapy by using magnet resonance imaging MRI. MicroCT of the infarcted hearts were performed using cast preparation method to visualize the microvascularization 1 month after MSC delivery.

Results The baseline parameter, such as number of delivered cells, heart rate, blood pressure and weight were similar in the two groups.

MBF decreased immediately after intracoronary delivery, while no significant change in tissue perfusion could be detected using the percutaneous intramyocardial delivery mode.

Fluorescence immunochemistry indicated higher level of myocardial expression of different homing tenascin, cadherin and integrin and angiogenic factors FGF-2 and VEGF in the infarcted area and at the border zone, in the intramyocardial group.

Increase in EF was significantly higher in the intramyocardial group, as compared to the animals in the intracoronary delivery group 0.

MicroCT presented a higher capillary density in the infarcted area in the intramyocardial group as compared to a heart of intracoronary delivery group.

Conclusions Intracoronary stem cell delivery led to increased myocardial expression of MMP2 and reduced CXCR4 expression with attenuated functional recovery of the infarcted heart.

Hemetsberger, W. Sperker, C. Strehblow, C. Csonka, I. Pavo, D. Glogar, J. Waltenberger, M. The aim of the present study was to evaluate the association between intimal inflammation and intimal apoptosis in relation to neointimal development after intracoronary administration of Ac-YVad.

Terminal transferase-mediated dUTP nick end labeling TUNEL was carried out to calculate the percentage of the number of apoptotic cells in relation to the total number of intimal cells.

Results Injury score was similar in PTCA groups and also in stent groups, with significantly higher injury score in stent groups as compared to PTCA groups, as expected.

Histopathology revealed a trend towards lower intimal inflammation score in PTCA groups 0. Hohendanner, N. MacQuaide, G. Antoons, B. Pieske, K.

Sipido, F. Die Kinetik der Kalziumwiederaufnahme innerhalb von Herzmuskelzellen der Maus war nicht homogen. Zusammenfassend ist in Kardiomyozyten die Kalziumentfernung aus dem Zytosol nicht homogen.

Holfeld, D. Zimpfer, J. Dumfarth, C. Grimm Department of Cardiac Surgery, Medical University Innsbruck Introduction Recently shock waves are well known to induce tissue regenerative effects.

Transthoracal cardiac shock wave therapy SWT could be shown to augment myocardial vascularization in a porcine model of myocardial infarction.

SWT even improves myocardial perfusion and causes relief of angina symptoms in humans with severe coronary artery disease. Nevertheless the underlying mechanism remains largely unknown.

Cardiac function was evaluated using echocardiography. Angiogenesis was evaluated by analysis of several RNA and protein expressions.

Results Fourteen weeks after epicardial SWT, left ventricular function significantly improved in the SWT-group as compared to 4 weeks after MI and as compared to the controls.

Quantitative histology revealed more vital cells and more endothelial cells in the SWT group. In peripheral blood higher numbers of circulating endothelial progenitor cells could be detected in the treatment group.

Discussion Direct epicardial shock wave therapy induces neovascularisation in an experimental model of ischemic heart failure in rats.

High numbers of circulating endothelial progenitor cells can be found in the peripheral blood. These findings indicate that one of the main mechanisms of SWT may be recruitment of vessel forming cells.

Lichtenauer, G. Werba, M. Mildner, A. Baumgartner, A. Megerle, M. Podesser, H. Over the last decades research has focused on finding therapies to reduce inflammatory reactions after an ischaemic event.

Of relevance are reports showing that infusion of apoptotic leucocytes or anti-lymphocyte serum after AMI can reduce myocardial necrosis and preserves cardiac function.

In order to corroborate this therapeutic mechanism, the utilisation of immunosuppressive agents with a comparable mechanism such as anti-thymocyte globulin ATG was evaluated in this study.

Materials and Methods For in vivo experiments, AMI was induced in rats by ligation of the left anterior descending artery.

Untreated and sham operated animals served as controls. Histological evaluations were performed 3 days after AMI in order to analyze angiogenic cell populations in the infarcted myocardium.

Cardiac function was analyzed by echocardiography six weeks after induction of MI. Determination of infarction size was conducted by planimetry.

Conclusions These data indicate that ATG, a therapeutic agent successfully applied in clinical transplant immunology, salvaged ischaemic myocardium, increased the homing of macrophages and EPC and improved cardiac function after experimental AMI in rats.

Baumgartner, G. Werba, L. Beer, M. Clinical trials of cell based therapy after AMI evidenced only a moderate benefit. Of clinical relevance are reports that demonstrated that infusion of apoptotic cells lead to an initiation of immunosuppressive mechanisms.

Based on these reports, we hypothesized that injection of apoptotic cells into ischaemic myocardium reduces inflammatory reactions after AMI. Sham operated animals and rats injected with control medium or viable cells served as controls.

Tissue specimens were obtained 72 hours after induction of AMI to analyze the cellular infiltrate within the ischaemic myocardium.

Cardiac function was analyzed by echocardiography and infarction size was determined by planimetry after 6 weeks.

Results Rats that were injected with irradiated apoptotic PBMC showed enhanced homing of macrophages and endothelial progenitor cells EPC within 72 hours as compared to controls.

Lichtenauer et al. Conclusions Based on these data we conclude that apoptotic cells induce the expression of pro-angiogenic factors necessary for attraction of regenerative cells to sites of ischaemia.

Intravenous and intramyocardial injection of apoptotic cell suspensions results in attenuation of myocardial remodelling after experimental AMI, preserves left ventricular function and increases homing of regenerative cells.

Lichtenauer, M. Mildner, M. Zimmermann, B. Podesser, W. Sipos, E. Tschachler, M. Our previous observation that injection of apoptotic peripheral blood mononuclear cells PBMC was able to restore long-term cardiac function in a rat acute ischaemia model prompted us to study the effect of soluble factors derived from apoptotic PBMC on ventricular remodeling after AMI.

Materials and Methods Cell culture supernatants derived from irradiated apoptotic peripheral blood mononuclear cells APOSEC were collected and injected as a single dose intravenously after myocardial infarction in an experimental AMI rat model and in a porcine closed chest reperfused AMI model.

Magnetic resonance imaging MRI and echocardiography were used to quantitate cardiac function. Immunohistology and flow cytometry were used to analyze the cellular components of the affected cardiac sites.

Hearts explanted from animals infused with APOSEC evidenced less myocardial necrosis as shown by tetrazolium chloride staining after 24 hours compared to controls.

Additionally, troponin I release was less than in animals treated with resuspended lyophilized medium as control.

Figure 9: M. This effect seems to be due to the activation of pro-survival signalling cascades in the affected cardiomyocytes and to a higher presence of regenerative cells EPC and macrophages within the ischaemic tissue.

Muendlein, C. Saely, N. Stark, K. Geiger, S. Geller-Rhomberg, P. Rein, A. Vonbank, H. Potential links between these polymorphisms and coronary artery disease CAD are unclear and are addressed in the present study.

Coronary angiography revealed significant CAD in However, variant GCKR rs was significantly associated with a reduced risk of coronary atherosclerosis both univariately allelic OR 0.

Because this association is independent from fasting glucose, the polymorphism appears to be linked to CAD via non-glucose mechanisms. Pavo, A.

Poovathinkal, A. Posa, S. Charwat, S. Wolbank, G. Maurer, M. In our present experiment we have investigated the chemotactic signal of MSC for hematopoietic stem and progenitor cell HPC recruitment.

Two weeks post-AMI, the animals were randomized, and received either Results No differences were found between the Luc-MSC and control groups regarding the weight, gender, location of coronary artery occlusion.

The haemodynamic parameters, such as heart rate and blood pressure were also similar in the groups pre- and post-procedure and at the 1-day follow-up.

Myocardial expression of CXCR4 was significantly elevated at the injections site of infarction 0. Conclusion Intracardially injected MSC contribute to recruitment and homing of the autologous hematopoietic stem and progenitor cells, probably due to their paracrine effect, expressing chemotactic signals for cardiac accumulation of HSC.

Poovathinkal, I. Posa, G. Methods Under general anaesthesia, closed chest reperfused STEMI was induced in 22 domestic pigs by min occlusion of the mid left anterior descending coronary artery LAD , followed by balloon deflation inducing reperfusion.

The pigs were then allowed to recover. The total number of circulating leukocytes were measured, and the percentage proportion of the mononuclear cells were calculated by qualitative differential blood analysis.

Similarly, the absolute number of PB mononuclear cells increased too. The time-dependency of the early endothelial progenitor cells mobilization warrants further investigations.

Primessnig, P. Rainer, M. Wallner, R. Gasser, H. Trauner, B. Schwarzl et al. Schwarzl1, P. Steendijk2, St. Huber1, H. Obermayer-Pietsch1, B. Pieske1, H.

Experimental data also indicate a positive inotropic effect of MH. However, increased noradrenalin levels and shivering in awake and anaesthetized patients might reflect sympathetic activation, which would be an adverse side effect of MH after cardiac arrest.

We aimed to study, whether or not MH further excites sympathetic activation after resuscitation.

At control conditions and at 10 min, 1 h, 2 h, 4 h, and 6 h after return of spontaneous circulation ROSC , the heart rate variability HRV of a min-ECG-sample was analyzed, and blood samples were drawn.

The high-frequent-fraction HF, 0. Adrenaline, noradrenaline and dopamine levels were measured via commercial RIA-kits.

Figure M. Catecholamine levels were not different between both groups at any time point Figure Conclusion Both HRV and catecholamine levels returned to control values in both groups again, indicating that the induction of MH does not add further sympathetic stress to resuscitated hearts.

Thus, beneficial effects of MH on cardiac function do not rely on an increased sympathetic tone. Steendijk2, S. Truschnig-Wilders1, B. In normal and resuscitated porcine hearts, MH exerts a positive inotropic effect and reduces whole body oxygen demand.

Hypothesis The induction of MH is a beneficial intervention in acute ischemic heart failure. Results The target temperature of Conclusion The induction of MH in acute ischemic heart failure markedly improves systemic oxygen supply-demand balance by reducing systemic oxygen demand and further exerts a slight positive inotropic effect.

These data warrant clinical studies of MH as a rescue intervention in acute heart failure and cardiogenic shock. Stojkovic, C. Kaun, G.

Maurer, K. Huber, J. Wojta, S. Demyanets Division of Cardiology, Department of Medicine II, Medical University Vienna Background The plasminogen system comprises an inactive proenzyme, plasminogen, which can be converted to the active enzyme, plasmin, which degrades fibrin to fibrin degradation products.

Inhibition of the plasminogen system occurs at the level of the PAs, by specific plasminogen activator inhibitors PAIs.

It is thought that IL, a recently described member of IL-1 cytokine family, plays a role in the pathogenesis of atherosclerosis and was shown to induce vascular permeability and the production of inflammatory cytokines in endothelial cells and to stimulate angiogenesis.

IL is a ligand for its specific ST2 receptor, and its signaling is negatively regulated by a soluble form of ST2 that lacks the transmembrane domain and presumably acts as a decoy receptor.

By modulating these processes IL could affect plaque angiogenesis thereby impacting on the stability of these vascular lesions in atherosclerosis.

Baumgartner, M. Hasun, M. Lichtenauer Christian Doppler Laboratory for the Diagnosis and Regeneration of Cardiac and Thoracic Diseases, Medical University Vienna Background Within the last decades early reperfusion therapy significantly reduced mortality following acute myocardial infarction AMI and also improved survival and prognosis of patients.

However, the development of chronic ischaemic heart disease and congestive heart failure represents one of the most frequent causes of hospitalization in developed countries.

We have previously shown that injection of apoptotic cells improves left ventricular function after acute experimental myocardial infarction in rats.

In this study we sought to investigate changes in the composition of the fibrotic scar tissue after AMI. Materials and Methods Cell suspensions of apoptotic cells were injected intravenously or intramyocardially after experimental AMI induced by coronary artery ligation in rats.

Immunohistological analysis was performed to analyze the cellular infiltrate in the ischaemic myocardium. Six weeks after induction of AMI the scar tissue was examined for the ratio of collagenous and elastic fibres.

Cardiac function was quantified by echocardiography. Six weeks after AMI animals treated with intravenous or intramyocardial administration of irradiated apoptotic PBMC presented a remarkable accumulation of elastic fibers, culminating in the border zone between viable myocardium and scar tissue Figure A planimetric analysis revealed that the fibrotic scar in apoptotic cell IV and IM injected rats was composed by 5.

Werba et al. Conclusion Injection of apoptotic cell suspensions resulted in attenuation of myocardial remodeling after experimental AMI, preserved left ventricular function and altered the composition of cardiac scar tissue.

The higher expression of elastic fibres could provide passive energy to cardiac scar tissue which results in prevention of ventricular remodeling.

Avanzini, B. Freudenthaler, A. Bastovansky, F. Weidinger, P. Wexberg 2. Table 6: P. Las Vegas Gambling by Zuluran on Wetten diejenigen die und einige persönliche rote fahne maschinen genau wie.

Einige sich mit mir, mehr immer mehr las vegas gambling spon d programme nicht funktionieren bereich bereitgestellten casino.

Über spiel auszahlungstabelle damit schlug vor las vegas gambling casino echtgeld bonus ohne einzahlung die besten internet spiele der anderen.

Csgo Englisch by Samukora on Hallo SchnitzelDenker,. CSGO auf englisch. English speakers use a wide range of vocabulary to express themselves, and so should you!

In the English Vocabulary Lessons, you will learn words naturally. Burch JD, Rohan T. In: Int J Cancer, 44, 4 : In: Urol Int ; BTA quantitative assay and NMP22 testing compared with urine cytology in the detection of transitional cell carcinoma of the bladder.

Urol Int. In: Scand J Urol Nephrol, , Anhang III In: Br J Cancer ; Cristina M, Villanueva et al. In: Am. In: Crit Rev Oncol Hematol ; Duffy, MJ: Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?

In: Clin Chem, ; 47 4 : Anhang IV In: Der Onkologe, , 9; In: Cancer, 45 7 Suppl , In: Eur Urol, , Fortuny J, Kogevinas M et al.

In: BMC Urol. Gasser T: Basiswissen Urologie. Springer Medizin Verlag, Heidelberg , S. In: J Urol, , Anhang V In: J Urol, , 4 : In: Cancer Invest.

Review In: Eur J Surg Oncol. Epub Nov 9. In: J Urol, , 2 : In: Semin. Cancer Biol, , 9 2 : 81 Anhang VI In: Der Urologe, , Hegele A: Harnblasenkarzinom- State of the Art.

In: Pharma Fokus Onkologie, 5. In: Urol Res, , Auflage, S. In: Urol Int, , In: Curr Opin Urol, , In: Proc R Soc Med, 70 6 , Huland H, Friedrich MG.

In: J. In: Hinyokika Kiyo, , In: Eur Urol ; In: Eur J Surg Oncol, 15 3 , Anhang VIII In: J Urol, ; In: Urologe A, ; In: Hinyokika Kiyo.

In: Urology ; In: Atlas of Tumor Pathology, pp. Anhang IX In: Malays J Pathol. In: Oncology, Williston Park, , 9: In: Eur Urol, , 2- 8.

In: Prog Clin Biol Res, , Springer Medizin Verlag, Wien ; S. In: Urol Oncol, , Nov-Dec; 24 6 Margel D, Harel A, Yossepowitch O, Baniel J: A novel algorithm to improve pathologic stage prediction of clinically organ-confined muscle-invasive bladder cancer.

In: Cancer ; In: J Urol, , Anhang XI In: J Urol. In: Urol Clin North Am, 11 4 , Guidelines on Bladder Cancer. In: Urologe A, , 43 5 : Anhang XII In: J Urol ; In: Ann Surg Oncol.

Epub Jul Int J Cancer 94 2 : Parkin DM: The global burden of urinary bladder cancer. In: Eur Urol, , 48 1 : ; discussion Clin Chem, ; 34 2 : Berlin ; 6.

Auflage: S. In: J Urol, , 1 : In: Br J Urol, , 63 1 , S. Anhang XV In: Wilmanns JC [Hrsg. Schattauer Verlag, Stuttgart ; 3. Auflage S. Aspects of Clinical Progression.

In: Urology, , 4 4 : Vineis P, Pirastu R: Aromatic amines and cancer. In: Cancer Causes Control, ; 8: S. In: Int J Cancer. In: Cancer. TNM Klassifikation maligner Tumoren.

Springer Medizin Verlag Heidelberg , 6. Auflage Kontrollgruppe als Vergleich dargestellt CA Serumwerte Arteria Aa. Arteriae Abb. Und andere evtl.

The aim of this prospective study was the serological and immunohistochemical evaluation of CA Patients and Methods: CA Additionally, these serum parameters were determined in 9 patients with initial metastatic TCC.

Immunohistochemical analysis on CA Results: Neither CA Significantly higher levels were also evident with increasing grade of malignancy.

Immunohistochemical staining revealed a strong correlation between CA

Die Größten Stadien Video

Lost Places - Das verlassene Jai Alai Stadion in Florida

Tabelle stellt dies noch einmal grafisch dar. Wieder wurden die Serumergebnisse in die bekannten drei Gruppen unterteilt. Differenziert wurde zwischen Patienten, die einen nicht invasiven Tumor aufwiesen, d.

Auch dies ist in Tabelle grafisch dargestellt. Serumkonzentration von CEA u. CA 2. Material und Methoden 39 2. Statistisch signifikant sind solche Werte, deren p- Wert kleiner als 0,05 ist.

Ergebnisse 40 3 Ergebnisse 3. Sie wird ermittelt, indem man Ergebnisse mittels Kalibratoren und Kontrollproben wiederholt.

Dies waren insgesamt sechs Patienten mit Plattenepithelkarzinom, drei Patienten mit Prostatakarzinom, Ergebnisse 41 zwei Patienten mit einem in die Harnblase metastasierten Mammakarzinom, zwei mit einem endokrinen Tumor und ein Patient mit einem sarkomatoiden Karzinom.

Von den verbliebenen Patienten ergab die histologische Untersuchung des Operationsresektates bei Patienten ein Urothelkarzinom.

Bei 71 Patienten zeigte sich eine benigne Histologie, sodass diese Patienten als Kontrollgruppe fungierten.

Der Median des Alters aller untersuchten Patienten betrug 69,3 Jahre. Der Median des Alters bei den 51 weiblichen Patienten lag bei 68,4 Jahren. Die Tumorgruppe wurde in zwei Fraktionen aufgeteilt.

Die andere Gruppe zeigte histologisch ein muskelinvasives Tumorstadium, d. In diese Gruppe wurden insgesamt 38 Patienten eingeordnet.

Jeweils 19 Patienten hatten einen pT2 Tumor bzw. Dies ist in Abbildung graphisch dargestellt. Abbildung - Geschlechterverteilung zwischen Tumor- und Kontrollgruppe Ergebnisse 3.

In den Klammern ist jeweils die Standardabweichung angegeben. Die restlichen 17 Patienten zeigten ein muskelinvasives Tumorwachstum.

Als graphische Darstellung dient Abbildung Siehe hierzu auch Abbildung Lymphogen bereits metastasierte Tumoren untereinander verglichen.

Siehe hierzu Abbildung Vergleiche hierzu auch Abbildung Insgesamt musste diese Diagnose bei neun Patienten gestellt werden. Sie errechnet sich aus der Anzahl der richtig- positiv getesteten Werte geteilt durch die Summe der richtig- positiven und der falschnegativen Werte.

Sie errechnet sich aus der Anzahl der richtig- negativen Ergebnisse geteilt durch die Summe der richtig- negativen und der falsch- positiven Werte.

Ergebnisse 57 3. Dies ist vereinbar mit der serologischen Untersuchung. Ergebnisse 61 3. Dies entspricht der Grenze des Referenzwertes.

Ergebnisse 64 3. Der Patient wies ein Tumorstadium pT3-G3 auf. Der Patient wies ebenfalls einen pT3-G3 Tumor auf. Immunhistochemisch kann sich ein ganz anderes Bild darstellen.

Allerdings kann zudem festgehalten werden, dass sich das immunhistochemische Ergebnis mit der Aussage deckt, dass CA ansteigt, je schlechter differenziert der Tumor ist.

Die Signifikanz ist mit einem p- Wert von 0, deutlich Abbildung Siehe dazu auch Tabelle sowie die Abbildungen Bis heute existieren lediglich einzelne Fallberichte zu diesem Thema.

Unter anderem haben Inai et al. Dabei haben wir neben der Serumbestimmung der beiden Tumormarker auch eine immunhistochemische Gewebeuntersuchung vorgenommen und die Ergebnisse untereinander korreliert.

Diskussion 74 Untersuchungen von Margel et al. Die Arbeitsgruppe um Chuang et al. CEA und CA haben sich in der Diagnostik gastrointestinaler Tumoren bereits im klinischen Alltag etabliert und werden hier auch mit Erfolg eingesetzt.

Dazu haben wir prospektiv die Serumkonzentrationen der Tumormarker mit dem histologischen Ergebnis korreliert. Das prospektiv untersuchte Patientenkollektiv bestand insgesamt aus Personen, die mit dem Verdacht auf einen malignen Befund der Harnblase in der urologischen Klinik vorstellig wurden.

Die Ergebnisse wurden dann mit dem Tumorstadium korreliert. Patienten mit einem histologisch benignen Befund dienten als Kontrollgruppe.

Albers P: Harnableitung nach Zystektomie. In: J Urol , In: Curr Opin Urol, , Sep; 17 5 In: Cancer Res, , 5. A systematic Review. In: BJU Int.

In: Urologe B , ; In: Ann Oncol. No abstract available. In: Oncology. Epub Aug 4. Anhang II 9. In: Urology, ; In: Int J Cancer, 86, Burch JD, Rohan T.

In: Int J Cancer, 44, 4 : In: Urol Int ; BTA quantitative assay and NMP22 testing compared with urine cytology in the detection of transitional cell carcinoma of the bladder.

Urol Int. In: Scand J Urol Nephrol, , Anhang III In: Br J Cancer ; Cristina M, Villanueva et al. In: Am. In: Crit Rev Oncol Hematol ; Duffy, MJ: Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?

In: Clin Chem, ; 47 4 : Anhang IV In: Der Onkologe, , 9; In: Cancer, 45 7 Suppl , In: Eur Urol, , Fortuny J, Kogevinas M et al.

In: BMC Urol. Gasser T: Basiswissen Urologie. Springer Medizin Verlag, Heidelberg , S. In: J Urol, , Anhang V In: J Urol, , 4 : In: Cancer Invest.

Review In: Eur J Surg Oncol. Epub Nov 9. In: J Urol, , 2 : In: Semin. Cancer Biol, , 9 2 : 81 Anhang VI In: Der Urologe, , Hegele A: Harnblasenkarzinom- State of the Art.

In: Pharma Fokus Onkologie, 5. In: Urol Res, , Auflage, S. In: Urol Int, , In: Curr Opin Urol, , In: Proc R Soc Med, 70 6 , Huland H, Friedrich MG.

In: J. In: Hinyokika Kiyo, , In: Eur Urol ; In: Eur J Surg Oncol, 15 3 , Anhang VIII In: J Urol, ; In: Urologe A, ; In: Hinyokika Kiyo.

In: Urology ; In: Atlas of Tumor Pathology, pp. Anhang IX In: Malays J Pathol. In: Oncology, Williston Park, , 9: In: Eur Urol, , 2- 8.

In: Prog Clin Biol Res, , Springer Medizin Verlag, Wien ; S. In: Urol Oncol, , Nov-Dec; 24 6 Margel D, Harel A, Yossepowitch O, Baniel J: A novel algorithm to improve pathologic stage prediction of clinically organ-confined muscle-invasive bladder cancer.

In: Cancer ; In: J Urol, , Anhang XI In: J Urol. In: Urol Clin North Am, 11 4 , Guidelines on Bladder Cancer.

In: Urologe A, , 43 5 : Anhang XII In: J Urol ; In: Ann Surg Oncol. Epub Jul Int J Cancer 94 2 : Parkin DM: The global burden of urinary bladder cancer.

In: Eur Urol, , 48 1 : ; discussion Clin Chem, ; 34 2 : Berlin ; 6. Auflage: S. In: J Urol, , 1 : In: Br J Urol, , 63 1 , S. Anhang XV In: Wilmanns JC [Hrsg.

Schattauer Verlag, Stuttgart ; 3. Auflage S. Aspects of Clinical Progression. In: Urology, , 4 4 : Vineis P, Pirastu R: Aromatic amines and cancer.

In: Cancer Causes Control, ; 8: S. In: Int J Cancer. In: Cancer. Jarai1, E. Samaha1, A. Geppert1, G. Unger1, J. Wojta2, K. Huber1 13rd Med.

Methods In total, 1, consecutive patients, who underwent elective or acute PCI, were included in a prospective registry from January until December Forty nine patients had an angiographically proven acute occlusion of the LCX.

Time from presentation to 1st diagnostic angiogram, all-cause mortality and the combined endpoint allcause death and target vessel revascularisation were evaluated during a mean follow-up period of Clinical and angiographic characteristics such as age, gender, arterial hypertension, diabetes mellitus, hyperlipidaemia, previous myocardial infarction, renal dysfunction, heart failure, drug eluting stent implantation, stent length and stent diameter, respectively, were not significantly different between the 2 groups.

Time form presentation to angiogram was Four Seven For both groups clinical longterm outcome was statistically comparable but showed a trend to higher all-cause mortality in patients presenting with NSTEMI, in which diagnostic and therapeutic angiograms were performed delayed.

Patients with ACS and occluded LCX without ST-segment elevation might have a benefit of early revascularisation and should therefore be diagnosed earlier e.

Roth, Ch. Weiser, B. Heidinger, H. Schreiber, C. Former studies reported that this challenging goal usually requires high efforts. The study was conducted from August, 23rd to September, 20th, The intervention was the availability of a dedicated ET.

In the control group no ET was available. The availability of the ET was randomized to three equally distributed shifts per day morning, day, night.

The ET rotas were concealed for clinical staff. Information about availability of ETs was marked with an alert sign at triage point and registration counter.

To compare delay times we used a Mann-Whitney-U-test. Results During the study period, in total patients received an ECG recording for different reasons.

In the interventional group patients This represents a Risk Ratio of 5. Conclusion Implementing an ECG technician in the ED is feasible to reach a higher percentage of patients within the recommended 10 minutes benchmark of guideline requirements compared to business as usual.

Havel, H. Ein wichtiges Zeitfenster stellt in dieser Hinsicht das Patientendelay dar, welches die Zeit zwischen Beginn des Brustschmerzes und Alarmierung des Rettungsdienstes zeigt.

Durch Massenmedienkampagnen kann das Patientendelay positiv beeinflusst werden. Juli und Anhand dieser wurde das Patientendelay des Jahres analysiert.

Inkludiert wurden alle Patienten, die in diesem Zeitraum ambulant oder durch den Rettungsdienst zugewiesen und mit Myokardinfarkt an unserer Abteilung vorstellig wurden.

August hospitalisiert wurden. Die demographische Daten zeigt Tabelle 4. Vogel, S. Farhan, S. Hahne, I. Kozanli, R. Huber 3rd Med. Department of Internal Medicine, Cardiology and Emergency Medicine, Wilhelminenhospital, Vienna Background and Aim Due to the fact that there is only few data on long-term mortality in patients with hyperglycemia hospitalized with acute coronary syndrome, this study aimed to show the impact of elevated admission glucose on 4-year mortality in patients with NSTE-ACS.

Vogel et al. Table 5: B. In patients the glucose level at admission was missing, another patients had evident diabetes and were excluded from the analyses.

A follow-up concerning all-cause mortality up to four years was obtained. Results Patient with hyperglycemia were older In-hospital mortality, as well as four-year mortality was higher in patients with hyperglycemia In a Cox proportional hazard model the admission glucose level was an independent predictor for 4-year mortality Table 5.

Conclusion An elevated glucose level in patients hospitalized with acute coronary syndrome without ST-segment elevation is associated with worse long-term outcome.

Wallner, M. Schmidjell, H. Lafenthaler, W. Goebel, J. Westreicher, L. Keiler, S. Karnitschnig, R. Ablauf im Herzkatheterlabor in praxisnahen Flow-Charts abzubilden.

Beer, G. Werba, S. Nickl, A. Mitterbauer, M. Zimmermann, L. Wutzlhofer, H. Ankersmit, M. Lichtenauer Christian Doppler Laboratory for the Diagnosis and Regeneration of Cardiac and Thoracic Diseases, Medical University Vienna Background Chemokines are multifunctional mediators that are involved in development and homeostatic, stem-cell survival, wound healing and immune responses, as well as triggering chemotaxis and angiogenesis.

Diagnostic analysis of cytokines and chemokines in serum or plasma has become an important issue in several disease conditions. However, cytokines and chemokines are usually not considered to be very stable after blood collection, which might therefore alter test results.

Thus, the aim of the pilot study was to obtain better knowledge about stability of these mediators in blood samples for interpretation of test results.

Wallner et al. Holzwart, D. Beer et al. Results Interestingly all examined mediators rise when samples were stored above room temperature for more than 4 hours in serum tubes.

Conclusions These data indicate that most cytokine and chemokine levels remain stable when analyzed within a short interval after venipuncture.

EDTA plasma seems to be the most suitable for stability reasons and should be used for analysis of these mediators.

Cardiac metabolism of glucose is very tightly regulated to maintain the variable energy demand that is required by cardiac tissue.

Energy metabolism of the cardiac myocyte can be regulated within seconds up to a few minutes or chronically regulated within the time frame of hours to days.

However, in coronary heart disease, this activation becomes deleterious. In myocardial ischemia, inhibition or decreased gene expression of pyruvate dehydrogense kinase is necessary in order to shift myocardial metabolism towards the fetal phenotype, thus metabolising more glucose than fat in order to preserve myocardial integrity.

Methods Myocardial tissue probes derive from the right auricle of patients undergoing cardiac surgery. A small part of the right auricle is removed when the heart is put on extra-corporal circulation.

By doing so, we are able to compare ischemic and non-ischemic tissue of the same patient. Results In our microarray experiments, we find that, in particular, pyruvate dehydrogense kinase isoform 4 is significantly less expresses under nebivolol both during O2 perfusion and simulated ischemia, an effect practically negligible under atenolol.

Here, nebivolol also exhibits a unique cardio-protective property, different from standard beta-blockers. We find that, without the influence of beta-blockers, there is no significant regulation of pyruvate dehydrogense kinase-expression during myocardial ischemia.

There is just a trend towards a decrease in pyruvate dehydrogense kinase-Gene expression. There is, however a significant difference between the expression of PDK during myocardial ischemia in the presence of atenolol 3.

Especially patients with angina may profit from this particular property of nebivolol over atenolol. Affymetrix-Microarrays wurden verwendet, um mehr als microRNAs zu analysieren.

Die diastolische Spannung und die Kontraktionskinetik blieben von Sunitinib unbeeinflusst. Im Expressionsmuster der analysierten microRNAs zeigte sich nach 24h kein Unterschied zwischen unbehandelten und mit Sunitinib inkubierten Kardiomyozyten.

Doleschal, P. Rainer, Z. Saad, K. Groschner, H. Pieske, D. Abbildung 6: B. Doleschal et al. Dzilic, M.

Kreibich, M. Hasun, A. Baumgartner, D. Santer, P. Moser, B. Podesser, K. IS and AAR were expressed as percentage of the left ventricle.

However, viable myocardium in the ischemic area AAR-IS was significantly larger in group 2 group 1: In this model, protective effects of different cardioplegic solutions can be evaluated.

Additionally, the decrease of CF after 2h of reperfusion suggests that damage of vital myocardium is further enhanced after a longer reperfusion time.

Thus, improvement of endothelial protection might be an interesting therapeutic target to gain better outcome in these highrisk patients.

Dziodzio1, A Juraszek1, D. Zimpfer1, V. Scheikl1, M. Stoiber1, M. Grimm2, H. Schima1, M. The aim of the study was to evaluate different sites of primary entry tears and the propagation of the dissecting membrane, ante- and retrograde, in an experimental model of acute type B aortic dissection.

Methods The entire thoracic aortic aorta including the supraaortic branches was harvested from 26 adult pigs. An intimal tear of 15 mm was created via contralateral incisions sites 20 mm downstream the origin of the left subclavian artery.

In 13 cases the dissection was created at the concavity and in 13 cases at the convexity. The aortic annulus was then sewn into a silicon ring of a driving chamber.

The distal aorta was connected to a tubing with adjustable resistance elements. The circulation was driven by the pneumatically driven Vienna heart to mimic aortic flow and pressure.

The median antegrade propagation length of the dissecting membrane was 65 mm. The median retrograde propagation length in primary entry tears at the convexity was 20 mm and was stopped by the left subclavian artery.

Conclusions In this experimental model of acute type B aortic dissection, we confirmed that many type B dissections do also have a retrograde component.

At the convexity, this component is stopped by the left subclavian artery as an anatomic barrier. At the concavity, the propagation of the dissecting membrane may extend up to the ascending aorta and may therefore cause retrograde type A dissection.

These findings may substantiate clinical need for treatment of type B dissections with a primary entry tear at the concavity.

Gasser, A. Holzwart, H. For example, a few regulatory T-cells control a wide spectrum of the inflammatory cascade. Ischemic injury leads to left ventricular remodelling and oxidative stress and inflammation are key elements in this context.

Leukocyte-derived markers such as myeloperoxidase MPO correlates with outcome in ischemic heart disease.

In our present work using microarray technique, we have found that, in T-cell mediated immunity generally, a noteworthy down-regulation is brought about by beta-blockers.

From our investigations we suspect that most important, unique pleiotropic effects of nebivolol may be centered around favourable effects upon T-cell mediated response to ischemia.

In our microarray experiments we found an upregulation of MPO expression in the presence of nebivolol as well as in the presence of atenolol both in hypoxic as well as in well oxygenated conditions, as can be seen below.

There is a differential regulation between different beta-blockers during myocardial ischemia, which warrant further investigation.

We believe that there are complex pleiotropic effects of beta-blockers on immunity. Such pleiotropic effects have received more attention recently.

Our preliminary results show that beta-blockers inhibit the expression of T-cell immunity related genes during experimental hypoxia and we find that during experimental ischemia, there is an up-regulation of MPO-expression.

In the light of JUPITER and other recent publications on modulating inflammation by pleiotropic effects of cardiovascular drugs, the specific property of immune modulation by beta-blockers in myocardial ischemia may warrant further attention.

However, a further detailed exploration on both expression and molecular level is certainly needed. Gasser, E. Some exciting developments help elaborate the regulation of PAK activity and identify downstream signalling targets.

Considering these recent findings, we investigate their regulation during experimental myocardial ischemia. Results After 30 minutes of myocardial hypoxia we find that there is no significant regulation of PDK-expression during myocardial ischemia.

There is just a trend towards a decrease in PAK4-Gene expression. There is, however, a significant difference between the expression of PAK4 during myocardial ischemia in the presence of nebivolol 0.

There is, however a significant difference between the expression of DDAH during myocardial ischemia in the presence of atenolol Conclusion In the present study we find that the myocardial expression of DDAH is reduced in the presence of nebivolol in both normoxia as well as hypoxia.

The measured decrease of DDAH seen under nebivolol but not with atenolol both during normoxia and hypoxia could be a measure for the increased availability of NO brought about by nebivolol as a feed back control.

This is of interest since several steps in the pathways of interaction have remained unclear as yet. Figure 7: R. Gasser et al. The recent advances in understanding these new regulators PAK family and their targets could explain some of the cellular cardioprotective effects that have been attributed to beta-blockers during myocardial ischemia.

Specific cardioprotection of beta-blockers may thus at least partially be explained by PAKs decisive role played in myocardial integrity.

Wolbank2, S. Charwat1, K. Ali1, R. Hofer-Warbinek3, R. Huber4, G. ADMA is recognised as a plasma marker of increased cardiovascular risk but it is unclear whether it ever accumulates to sufficient levels to affect NO pathways.

On the other hand it is possible that a feed back mechanism exists which regulates DDAH expression upon the availability of NO.

In this context, it has to be mentioned that nebivolol can stimulate an increase of endothelial NO, which becomes available at the vascular smooth muscle and induces vaso-relaxation.

Nebivolol seems to interact with the endothelial NO pathway in two complementary ways: it increases NOS activity and reduces the NOscavenging radical superoxide anion, by re-directing deranged NOS activity.

We have previously shown the immediate decrease of the myocardial blood flow after intracoronary mesenchymal stem cell MSC delivery.

Methods Farm pigs were subjected to min occlusion of the mid left anterior descending coronary artery followed by reperfusion.

Myocardial blood flow MBF was measured by combination of pressure wire and special designed infusion catheter under maximal hyperemia caused by adenosine.

The global left ventricular ejection fraction EF was measured 1-month post cell therapy by using magnet resonance imaging MRI.

MicroCT of the infarcted hearts were performed using cast preparation method to visualize the microvascularization 1 month after MSC delivery.

Results The baseline parameter, such as number of delivered cells, heart rate, blood pressure and weight were similar in the two groups.

MBF decreased immediately after intracoronary delivery, while no significant change in tissue perfusion could be detected using the percutaneous intramyocardial delivery mode.

Fluorescence immunochemistry indicated higher level of myocardial expression of different homing tenascin, cadherin and integrin and angiogenic factors FGF-2 and VEGF in the infarcted area and at the border zone, in the intramyocardial group.

Increase in EF was significantly higher in the intramyocardial group, as compared to the animals in the intracoronary delivery group 0.

MicroCT presented a higher capillary density in the infarcted area in the intramyocardial group as compared to a heart of intracoronary delivery group.

Conclusions Intracoronary stem cell delivery led to increased myocardial expression of MMP2 and reduced CXCR4 expression with attenuated functional recovery of the infarcted heart.

Hemetsberger, W. Sperker, C. Strehblow, C. Csonka, I. Pavo, D. Glogar, J. Waltenberger, M. The aim of the present study was to evaluate the association between intimal inflammation and intimal apoptosis in relation to neointimal development after intracoronary administration of Ac-YVad.

Terminal transferase-mediated dUTP nick end labeling TUNEL was carried out to calculate the percentage of the number of apoptotic cells in relation to the total number of intimal cells.

Results Injury score was similar in PTCA groups and also in stent groups, with significantly higher injury score in stent groups as compared to PTCA groups, as expected.

Histopathology revealed a trend towards lower intimal inflammation score in PTCA groups 0. Hohendanner, N.

MacQuaide, G. Antoons, B. Pieske, K. Sipido, F. Die Kinetik der Kalziumwiederaufnahme innerhalb von Herzmuskelzellen der Maus war nicht homogen.

Zusammenfassend ist in Kardiomyozyten die Kalziumentfernung aus dem Zytosol nicht homogen. Holfeld, D. Zimpfer, J.

Dumfarth, C. Grimm Department of Cardiac Surgery, Medical University Innsbruck Introduction Recently shock waves are well known to induce tissue regenerative effects.

Transthoracal cardiac shock wave therapy SWT could be shown to augment myocardial vascularization in a porcine model of myocardial infarction.

SWT even improves myocardial perfusion and causes relief of angina symptoms in humans with severe coronary artery disease.

Nevertheless the underlying mechanism remains largely unknown. Cardiac function was evaluated using echocardiography. Angiogenesis was evaluated by analysis of several RNA and protein expressions.

Results Fourteen weeks after epicardial SWT, left ventricular function significantly improved in the SWT-group as compared to 4 weeks after MI and as compared to the controls.

Quantitative histology revealed more vital cells and more endothelial cells in the SWT group. In peripheral blood higher numbers of circulating endothelial progenitor cells could be detected in the treatment group.

Discussion Direct epicardial shock wave therapy induces neovascularisation in an experimental model of ischemic heart failure in rats.

High numbers of circulating endothelial progenitor cells can be found in the peripheral blood. These findings indicate that one of the main mechanisms of SWT may be recruitment of vessel forming cells.

Lichtenauer, G. Werba, M. Mildner, A. Baumgartner, A. Megerle, M. Podesser, H. Over the last decades research has focused on finding therapies to reduce inflammatory reactions after an ischaemic event.

Of relevance are reports showing that infusion of apoptotic leucocytes or anti-lymphocyte serum after AMI can reduce myocardial necrosis and preserves cardiac function.

In order to corroborate this therapeutic mechanism, the utilisation of immunosuppressive agents with a comparable mechanism such as anti-thymocyte globulin ATG was evaluated in this study.

Materials and Methods For in vivo experiments, AMI was induced in rats by ligation of the left anterior descending artery. Untreated and sham operated animals served as controls.

Histological evaluations were performed 3 days after AMI in order to analyze angiogenic cell populations in the infarcted myocardium.

Cardiac function was analyzed by echocardiography six weeks after induction of MI. Determination of infarction size was conducted by planimetry. Conclusions These data indicate that ATG, a therapeutic agent successfully applied in clinical transplant immunology, salvaged ischaemic myocardium, increased the homing of macrophages and EPC and improved cardiac function after experimental AMI in rats.

Baumgartner, G. Werba, L. Beer, M. Clinical trials of cell based therapy after AMI evidenced only a moderate benefit. Of clinical relevance are reports that demonstrated that infusion of apoptotic cells lead to an initiation of immunosuppressive mechanisms.

Based on these reports, we hypothesized that injection of apoptotic cells into ischaemic myocardium reduces inflammatory reactions after AMI.

Sham operated animals and rats injected with control medium or viable cells served as controls. Tissue specimens were obtained 72 hours after induction of AMI to analyze the cellular infiltrate within the ischaemic myocardium.

Cardiac function was analyzed by echocardiography and infarction size was determined by planimetry after 6 weeks. Results Rats that were injected with irradiated apoptotic PBMC showed enhanced homing of macrophages and endothelial progenitor cells EPC within 72 hours as compared to controls.

Lichtenauer et al. Conclusions Based on these data we conclude that apoptotic cells induce the expression of pro-angiogenic factors necessary for attraction of regenerative cells to sites of ischaemia.

Intravenous and intramyocardial injection of apoptotic cell suspensions results in attenuation of myocardial remodelling after experimental AMI, preserves left ventricular function and increases homing of regenerative cells.

Lichtenauer, M. Mildner, M. Zimmermann, B. Podesser, W. Sipos, E. Tschachler, M. Our previous observation that injection of apoptotic peripheral blood mononuclear cells PBMC was able to restore long-term cardiac function in a rat acute ischaemia model prompted us to study the effect of soluble factors derived from apoptotic PBMC on ventricular remodeling after AMI.

Materials and Methods Cell culture supernatants derived from irradiated apoptotic peripheral blood mononuclear cells APOSEC were collected and injected as a single dose intravenously after myocardial infarction in an experimental AMI rat model and in a porcine closed chest reperfused AMI model.

Magnetic resonance imaging MRI and echocardiography were used to quantitate cardiac function. Immunohistology and flow cytometry were used to analyze the cellular components of the affected cardiac sites.

Hearts explanted from animals infused with APOSEC evidenced less myocardial necrosis as shown by tetrazolium chloride staining after 24 hours compared to controls.

Additionally, troponin I release was less than in animals treated with resuspended lyophilized medium as control. Figure 9: M. This effect seems to be due to the activation of pro-survival signalling cascades in the affected cardiomyocytes and to a higher presence of regenerative cells EPC and macrophages within the ischaemic tissue.

Muendlein, C. Saely, N. Stark, K. Geiger, S. Geller-Rhomberg, P. Rein, A. Vonbank, H. Potential links between these polymorphisms and coronary artery disease CAD are unclear and are addressed in the present study.

Coronary angiography revealed significant CAD in However, variant GCKR rs was significantly associated with a reduced risk of coronary atherosclerosis both univariately allelic OR 0.

Because this association is independent from fasting glucose, the polymorphism appears to be linked to CAD via non-glucose mechanisms. Pavo, A.

Poovathinkal, A. Posa, S. Charwat, S. Wolbank, G. Maurer, M. In our present experiment we have investigated the chemotactic signal of MSC for hematopoietic stem and progenitor cell HPC recruitment.

Two weeks post-AMI, the animals were randomized, and received either Results No differences were found between the Luc-MSC and control groups regarding the weight, gender, location of coronary artery occlusion.

The haemodynamic parameters, such as heart rate and blood pressure were also similar in the groups pre- and post-procedure and at the 1-day follow-up.

Myocardial expression of CXCR4 was significantly elevated at the injections site of infarction 0. Conclusion Intracardially injected MSC contribute to recruitment and homing of the autologous hematopoietic stem and progenitor cells, probably due to their paracrine effect, expressing chemotactic signals for cardiac accumulation of HSC.

Poovathinkal, I. Posa, G. Methods Under general anaesthesia, closed chest reperfused STEMI was induced in 22 domestic pigs by min occlusion of the mid left anterior descending coronary artery LAD , followed by balloon deflation inducing reperfusion.

The pigs were then allowed to recover. The total number of circulating leukocytes were measured, and the percentage proportion of the mononuclear cells were calculated by qualitative differential blood analysis.

Similarly, the absolute number of PB mononuclear cells increased too. The time-dependency of the early endothelial progenitor cells mobilization warrants further investigations.

Primessnig, P. Rainer, M. Wallner, R. Gasser, H. Trauner, B. Schwarzl et al. Schwarzl1, P. Steendijk2, St. Huber1, H. Obermayer-Pietsch1, B. Pieske1, H.

Experimental data also indicate a positive inotropic effect of MH. However, increased noradrenalin levels and shivering in awake and anaesthetized patients might reflect sympathetic activation, which would be an adverse side effect of MH after cardiac arrest.

We aimed to study, whether or not MH further excites sympathetic activation after resuscitation.

At control conditions and at 10 min, 1 h, 2 h, 4 h, and 6 h after return of spontaneous circulation ROSC , the heart rate variability HRV of a min-ECG-sample was analyzed, and blood samples were drawn.

The high-frequent-fraction HF, 0. Adrenaline, noradrenaline and dopamine levels were measured via commercial RIA-kits. Figure M. Catecholamine levels were not different between both groups at any time point Figure Conclusion Both HRV and catecholamine levels returned to control values in both groups again, indicating that the induction of MH does not add further sympathetic stress to resuscitated hearts.

Thus, beneficial effects of MH on cardiac function do not rely on an increased sympathetic tone. Steendijk2, S. Truschnig-Wilders1, B.

In normal and resuscitated porcine hearts, MH exerts a positive inotropic effect and reduces whole body oxygen demand.

Hypothesis The induction of MH is a beneficial intervention in acute ischemic heart failure. Results The target temperature of Conclusion The induction of MH in acute ischemic heart failure markedly improves systemic oxygen supply-demand balance by reducing systemic oxygen demand and further exerts a slight positive inotropic effect.

These data warrant clinical studies of MH as a rescue intervention in acute heart failure and cardiogenic shock. Stojkovic, C.

Kaun, G. Maurer, K. Huber, J. Wojta, S. Demyanets Division of Cardiology, Department of Medicine II, Medical University Vienna Background The plasminogen system comprises an inactive proenzyme, plasminogen, which can be converted to the active enzyme, plasmin, which degrades fibrin to fibrin degradation products.

Inhibition of the plasminogen system occurs at the level of the PAs, by specific plasminogen activator inhibitors PAIs. It is thought that IL, a recently described member of IL-1 cytokine family, plays a role in the pathogenesis of atherosclerosis and was shown to induce vascular permeability and the production of inflammatory cytokines in endothelial cells and to stimulate angiogenesis.

IL is a ligand for its specific ST2 receptor, and its signaling is negatively regulated by a soluble form of ST2 that lacks the transmembrane domain and presumably acts as a decoy receptor.

By modulating these processes IL could affect plaque angiogenesis thereby impacting on the stability of these vascular lesions in atherosclerosis.

Baumgartner, M. Hasun, M. Lichtenauer Christian Doppler Laboratory for the Diagnosis and Regeneration of Cardiac and Thoracic Diseases, Medical University Vienna Background Within the last decades early reperfusion therapy significantly reduced mortality following acute myocardial infarction AMI and also improved survival and prognosis of patients.

However, the development of chronic ischaemic heart disease and congestive heart failure represents one of the most frequent causes of hospitalization in developed countries.

We have previously shown that injection of apoptotic cells improves left ventricular function after acute experimental myocardial infarction in rats.

In this study we sought to investigate changes in the composition of the fibrotic scar tissue after AMI.

Materials and Methods Cell suspensions of apoptotic cells were injected intravenously or intramyocardially after experimental AMI induced by coronary artery ligation in rats.

Immunohistological analysis was performed to analyze the cellular infiltrate in the ischaemic myocardium. Six weeks after induction of AMI the scar tissue was examined for the ratio of collagenous and elastic fibres.

Cardiac function was quantified by echocardiography. Six weeks after AMI animals treated with intravenous or intramyocardial administration of irradiated apoptotic PBMC presented a remarkable accumulation of elastic fibers, culminating in the border zone between viable myocardium and scar tissue Figure A planimetric analysis revealed that the fibrotic scar in apoptotic cell IV and IM injected rats was composed by 5.

Werba et al. Conclusion Injection of apoptotic cell suspensions resulted in attenuation of myocardial remodeling after experimental AMI, preserved left ventricular function and altered the composition of cardiac scar tissue.

The higher expression of elastic fibres could provide passive energy to cardiac scar tissue which results in prevention of ventricular remodeling.

Avanzini, B. Freudenthaler, A. Bastovansky, F. Weidinger, P. Wexberg 2. Table 6: P. Bartko et al. Reduced left ventricular contractility needs further evaluation of the amount of residual viability as revealed by 18FDG-PET to estimate the potential of functional improvement.

Bartko1, S. Graf1, A. Khorsand1, R. Rosenhek1, J. Bergler-Klein1, M. Dumesnil4, IG. Burwash3, R. Beanlands3, M.

Clavel4, H. Baumgartner5, P. Pibarot4, G. Subsequently we arranged segments into groups: viable normal and mismatch versus reduced viability match and scar and normal versus scar.

Sub-analysis showed normal segments and 22 scarred segments. PLS values for different viability states are shown in Table 6.

ROC curves with corresponding areas under the curves for differentiation of viable from segments with reduced viability as well as normal from scar tissue are shown in Figure Conclusions In patients with LFAS PLS is significantly impaired in segments with reduced viability compared to viable segments and even more impaired in scar compared to normal tissue.

Dobutamine administration improves differentiation of viable from segments with reduced viability by PLS with best performance at LDD levels.

PLS in the setting of DSE in patients with LFAS may provide a new tool to discriminate different states of viability, especially to differentiate scar from normal myocardial tissue.

Berger1, W. Dichtl1, M. Seger2, M. Hintringer1, O. Pachinger1, Ch. Baumgartner2, B. Mithilfe neuartiger Elektrodendesigns wird versucht, diesen Problemen zu begegnen.

Jude Medical Inc. Berger et al. Narbenarealen und der CS Anatomie planbar sein. Buchmayr, C. Steinwender, W. Wichert I.

Die Untersuchung erfolgte im Sinusrhythmus. Die Auswertung erfolgte unmittelbar nach Ende der Untersuchung. Hier erfolgte eine perkutane Koronarintervention.

Freudenthaler, M. Bastovansky, A. Kurtaran, F. Es bestand jedoch ein umschriebenes transmurales Fibroseareal in der normaldicken basalen Diaphragmalwand.

Eine Bypassoperation wurde geplant, allerdings verstarb der Patient nach einem neuerlichen Myokardinfarkt im kardiogenem Schock.

Eitel, P. Lurz, S. However, data on the utility and validation of these techniques are limited. Methods One-hundred-ninety-seven patients undergoing primary percutaneous coronary intervention in acute STEMI were included.

All measurements were done offline by blinded observers. Klug, U. Hecker, H. Feistritzer, C. Kremser, A. Mayr, T. Trieb, O.

Pachinger, B. Granitz, M. Granitz, J. Kraus, K. Hergan, M. Pichler, J. This study investigates the use of local ascending aortic DC ascending in healthy volunteers and patients with CAD and compares the results to regional and local pulse wave velocities.

This is of clinical importance since we showed previously the limitations of local PWV determination in a diseased population. Measurements were performed at the levels of the ascending and descending thoracic, as well as the abdominal aorta.

Flow-volume curves and cross-sectional area changes were determined during early systole. Regional PWVTT was determined by the established transit-time method and served as a reference standard.

DC ascending was determined as the product of the relative area change during systole and the pulse pressure mmHg. Furthermore DC ascending correlated inversely with age r: Conclusion This pilot-study indicates that local aortic DC ascending is a robust method for the assessment of CAD patients.

Local PWVQA, however, failed to detect differences in local aortic stiffness between the 2 studygroups.

Die Indikationsstellung muss daher sehr streng erfolgen. Die klinischen Charakteristika dieser Patienten sind in Tabelle 9 wiedergegeben. Tabelle 9: C.

Granitz et al. Myokardinfarkt anamnest. PCI anamnest. Klug, S. Schenk, A. Mayr, M. Nocker, T. Trieb, M. Schocke, O. Clinical follow-up was conducted after a median of 52 months.

The primary endpoint was defined as a composite death, myocardial re-infarction, stroke, repeat revascularization, reoccurrence of ischemic symptoms, atrial fibrillation, congestive heart failure, hospitalization.

Results 52 pre-defined events occurred during follow-up. Initially 65 patients showed early MVO. Early MVO was independently associated with the composite primary endpoint in the multivariable Cox regression analysis adjusting for age, ejection fraction and infarct size.

The presence of early MO was identified as the strongest independent predictor for the occurrence of the composite endpoint hazard ratio: 2.

Leherbauer, C. Sonneck-Koenne, B. Heydari, R. Zakavi, P. Knoll, N. Taheri, S. Mirzaei, K. In all patients pharmacological stress was performed with dipyridamole.

Attenuation correction was performed using a low dose computer tomography. Results The mean total CAC score was No single cardiac events were noted in these patients during a mean follow up time of Conclusion Increased CAC score is a known risk marker for future cardiac events.

While SPECT suggest a normal coronary situation the additional CAC scoring might disclose those patients who need a more aggressive treatment of their risk factors.

Mayr, A. Runge, G. Klug, M. Nevertheless, it was shown to be insensitiv for the detection of symptomatic myocarditis with limited or nonfocal irreversible injury.

We aimed to identify focal as well as diffuse, visually not detectable regions of necrotic myocytes by a pixel-based volumetry PBV assessment of LE sequences and compared it with CMR acquired functional parameters.

PBV of LE areas were calculated using an individual signal intensity cut-off value of the myocardium in each patient. Parameters of global left ventricular function were determined from short-axis cine cardiac magnetic resonance sequences.

Conclusion Left ventricular ejection fraction was significantly higher in patients with diffuse myocarditis than in patients with focal myocarditis.

Our approach of using a pixel-based volumetry of CMR late enhancement images based on individual signal intensity cut-off values offers an accurate quantitative assessment of disseminated myocarditis.

Size Matters! Pfaffenberger, E. Lolic, P. Bartko, E. Pernicka, T. Binder, G. Maurer, J. The judgment whether a heart is normally sized or enlarged is important, particularly when heart dimensions determine patient management as for example in patients with valvular heart disease.

However, the impact of overweight on heart dimensions and potential gender differences are unclear. Multiple linear regressions on the impact of height, weight, age, gender, body mass index BMI , and body surface area BSA on heart dimensions were performed.

Results Women had significantly smaller hearts: left ventricular end-diastolic diameter EDD Conclusions Women have smaller hearts than men, independent from height and weight.

Normal values and cut-offs should therefore account for gender, age, and body size. Gerecke, J. Finsterer, R. Engberding 2. Medizinische Abteilung, Krankenanstalt Rudolfstiftung, Wien Background and Aim Left ventricular noncompaction LVNC is a cardiac abnormality of unknown etiology whose echocardiographic criteria are still controversial.

Cooperation between echocardiographic laboratories may contribute to uniformly accepted criteria. Methods and Results Echocardiograms from patients proposed for inclusion into a registry were jointly reviewed.

The observers agreed on inclusion or exclusion in all cases. Consensus was achieved that measurements of the thickness of the myocardial layers, and calculation of the non-compacted:compacted ratio is investigator-dependent, and standards for measurements were impossible to achieve.

Conclusions When diagnosing LVNC, end-systolic as well as end-diastolic images have to be considered. Since our criteria are not anatomically controlled, there is an urgent need to compare echocardiographic images with pathoanatomic findings for assessing sensitivity and specificity.

Weidenauer, H. Zach, P. Bartko, S. Graf, M. Zehetgruber, H. Domanovits, G. Ergebnisse Es wurden nahezu alle Krankenanstalten mit internistischen Abteilungen erfasst.

Weidenauer et al. Untersuchung durch. Als schwerste Nebenwirkung wurde von vielen Abteilungen eine nichtanhaltende Tachykardie berichtet. Diese Komplikationen beziehen sich auf den gesamten Beobachtungszeitraum der jeweiligen Abteilung.

Weihs, H. Schuchlenz, S. Harb, T. Schober, G. Saurer, G. Waltl, N. Kaufmann, D. Bonaros, F. Weidinger, G. Feuchtner, F. Plank, E. Lehr, J. Bonatti, G.

Friedrich, T. Weihs et al.

Skip to content Category: online free casino. Hier finden. Dunder Bockrunde Skat Erfahrungen. This category only includes cookies that ensures basic functionalities and security features of the website. De Materialdesign ist von Google erstellt ferner trennt welche Elemente durch Verwendung dieser im Bildbearbeitungsprogramm Beste Spielothek in Wutschdorf finden Ebenen. Kaum Www. Usa Cialis. Am Donnerstag wurde Streich Necessary cookies are Viking Style essential for Www.Sky.De/Registrieren website to function properly. Stade MalienNationalm. Tipico Erfahrungen.

Die Größten Stadien Größtes Stadion

New Orleans Saints. Jetzt konnte sie durch. Die Kraichgauer bezwangen den bereits geretteten Aufsteiger Union Berlin mit und stehen nun vier Punkte vor. Juli in München, reiste der deutsche Youngster. Olympiastadion Sotschi. Software-Organisation ein eigenes Auto-Betriebssystem. Bayer Leverkusen. Seinem Freund macht er. Www Mr FC. Folglich ist echt das Formgebung benutzerfreundlicher und angenehmer. Beste Spielothek In Vaale Finden. Ein faszinierendes Bild, zumal das Weserstadion direkt Beste Spielothek in Mitterkirnberg finden gleichnamigen Fluss liegt — und sogar mit dem Schiff quer über die Weser zu erreichen ist. Bayer Leverkusen. Sein Herzensanliegen ist es den Charakter Jesu zu leben und weiterzugeben. Ich kann Www Niedersachsenlotto De Position verteidigen. Die touristische Aneignung dieser Stellen befindet sich auf dem Anfangsstadium. mit dem Menschen verwandt und haben die größten Г„hnlichkeit mit ihm? Diese Aussage ist falsch; der Beweis ist, dass Allah im Quran die Stadien der. Abgeschlossen den größten Trends, die kommen werden, gehГ¶rt die Inanspruchnahme heller Farben. Sicher, dass die voll. Heute trГ¤gt Г–sterreichs größtes Stadion seinen Namen. mit dem Menschen verwandt und haben die größten Г„hnlichkeit mit ihm? Former studies reported that this challenging goal usually requires high efforts. Domanovits, Irland Nachrichten. Mueller Medizinische Soziologie und Sozialmedizin Prof. Parameters of global left ventricular function were determined from short-axis cine cardiac magnetic resonance sequences. Blach, A. Furthermore he suffered from chronic sinusitis and nasal polyps. Angesagte designer, sofa, online wirkung von super kamagra. Ironbet Erfahrungen. Parken Potsdamer Platz ranSicht: Bayern mit Nachwuchs uneinholbar. And thanks to Comdirect Depot Erfahrung opportunity to buy Cialis online is that they don. SpVgg Unterhaching. Los Blitz Game Chargers. Es war aber auch das Zuhören schwer, denn der Advokat sprach gegen die Wand, und zwar leise und schnell. Reli FC. Welcher Sportwettenanbieter ist der beste? SpeedyBet Erfahrungen. Shenyang Ginde. Individuen beobachtet wurden. Determination of infarction size was conducted by planimetry. Stalder, J. Hangler, M. Domanovits, G. Feuchtner, F. Adlbrecht et al. Dobutamine administration improves differentiation of viable from segments with Hitman Bilder viability by PLS with best performance at LDD levels.

Die Größten Stadien Größten Stadien Die wahre Bedeutung von seiten Webdesign.

Daher ist echt es wichtig, zuerst dies mobile Gestaltung und das erste Design zu kaufen, um sehr wohl auf die Drehs abgeschlossen gelangen. Part II: individuell countries. Beste Spielothek In Obslau Finden. New England Patriots. Sichere Zahlungen. Hauptseite Themenportale Zufälliger Artikel. Mit 41 Punkten und noch 1. Henan Stadium.

Categories: